Celiac disease could be deactivated and not require a diet without gluten forever

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The celiac disease is a chronic disease in which the body reacts to the presence of gluten in the intestines and damages the villi of this body. Although celiac disease has no cure recently, it is thought that it could be deactivated and not require a gluten-free diet forever .

The switch of celiac disease

It is known that the immunological reaction that occurs in the presence of gluten in the intestine is mediated by an enzyme called transglutaminase 2 or TG2 . Although this enzyme is also present in the intestine of healthy people, it is inactive and therefore does not trigger the adverse reaction that characterizes celiac patients.

The key then was to know what activates and what turns off this enzyme that may be the main cause of celiac disease. A recent study by researchers at Stanford University seems to have found the answer.

Celiac disease could be deactivated and not require a diet without gluten forever

TG2 is activated when a disulfide bond is broken and when it is recreated, it can be inactivated. Recently it is known that endoplasmic reticulum protein 57 or ERp57 is able to deactivate this enzyme that generates celiac disease and therefore, it is believed that the switch has been found that would allow celiacs not to carry a gluten-free diet forever.

Given that previous studies in rodents showed that the deactivation of TG2 does not cause side effects, it is believed that using ERp57 as part of different medicines could be the key to deactivating celiac disease in the not too distant future and thus, who until now they depended on a gluten-free diet to control the disease, do not continue in the same situation.

Bibliography consulted | Semin Immunopathol . 2012 Jul; 34 (4): 513-522; The Journal of Biological Chemistry , 293, 2640-2649; and PLoS One . 2012; 7 (2): e30642.
Image | iStock

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